Welcome to FOXODB

FOXODB is a database aimed at manually collecting experimentally verified direct targets of FOXO transcription factors (FOXOs). FOXOs are at the interface of crucial cellular processes, orchestrating programs of gene expression that regulate apoptosis, cell-cycle progression, and oxidative stress resistance. In invertebrates, there is only one FOXO gene, termed daf-16 in the worm and dFOXO in the fly. In mammals, there are four FOXO genes, FOXO1, FOXO3, FOXO4, and FOXO6. Currently, FOXODB collects about 300 entries including more than 200 FOXOs direct targets. We believe FOXODB will be a valuable resource for related research community.

There are strict rules to collect a gene to FOXODB: (1) the gene must be differentially expressed in FOXO(+) versus FOXO(-); (2) FOXO could bind to the promoter region of the gene; and (3) since the high false positive of high throughput experiment, only tranditional experimental evidences were used.

Symbol Species Regulated by Up or Down Qutantitation Method Binding detection Method Function Worm Ortholog PMID GeneID dbXrefs More

All data can be downloaded from here


Orthologs of FOXOs direct targets:


Citation: Y.H. Li, G.G. Zhang, Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans, Oncotarget, (2016). PMID: 27027346

FOXODB Tutorial

Yan-Hui Li

December, 2015

FOXO transcription factors belong to the large family of Forkhead proteins. FOXO subfamily is conserved from Caenorhabditis elegans to mammalians. Invertebrates have only one gene whereas mammalians have four FOXO family members: FOXO1 (FKHR) FOXO3 (FKHRL1), FOXO4 (AFX) and FOXO6. FOXO1, 3 and 4 are ubiquitously expressed, while FOXO6 expression is restricted to brain.FOXOs play critical roles in a wide variety of cellular processes, including proliferation, apoptosis, autophagy, metabolism, inflammation, differentiation and stress resistance.

Here, we setup FOXODB, a manually curated database, aiming at collect experimentally validated FOXOs direct targets. Currently, FOXODB covers about 300 entries, including more than 200 direct targets. Detailed information on how to use FOXODB is as following:

1. Visiting FOXODB:

Log on FOXODB at http://lyh.pkmu.cn/foxodb/, as shown in Figure 1.

Figure 1.Homepage of FOXODB

2. Browse.

2.1 Click the menu "Browse" (red "1" in Figure 2).

2.2 Click the tree node and browse all data in the FOXODB (red "2" in Figure 2). When a gene is selected (red "3" in Figure 2), the detailed information will display on the right side, as shown in red "4" in Figure 2).

Figure 2. Browse the FOXODB

3. Search.

3.1 Click the menu "Search" (red "1" in Figure 3.1). Input the word(s) such as "DAF-16" in red "2", the table will automatically list the search results as shown in red "3". Then, user can print the results by clicking red "4", browse the results page by page by clicking red "6", or change the number of entries shown in each page by choosing from a submenu in red "5". To known further information about a target gene, user can click red "7", then further information could be found in Figure 3.2.

Figure 3.1 Search the FOXODB

3.2 Detailed gene information. This page list detailed information about a target gene. Extra information could be found by clicking the links in red "1 and 2" in Figure 3.2.

Figure 3.2 Detailed gene information

4. Data download

All data could be downloaded from FOXODB. Click red "1" in Figure 4, and then choose the data in red "2".

Figure 4 Download data from FOXODB

    Feel free to contact:

    Dr. Yan-Hui Li

    Institute of Cardiovascular Sciences, Peking University Health Science Center

    38 Xueyuan Rd, Beijing 100191 China

    Email: liyanhui@hsc.pku.edu.cn