Symbol Species Regulated by Up or Down Qutantitation Method Binding Detection Method Function Worm Ortholog PMID geneid dbXrefs Description aakg-4 C. elegans DAF-16 up Microarray;qRT-PCR DamID Signalling aakg-4 20706209 187928 WormBase:WBGene00020135 hypothetical protein aay Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay EMSA;Luciferase Reporter Assay Growth Y62E10A.13 "18299344 " 39085 FLYBASE:FBgn0023129 astray ABCB1 Human FOXO1 up Luciferase Reporter Assay;Western blotting Luciferase Reporter Assay+Mutation;EMSA Drug ressistance pgp-9;pgp-1 "18390843 " 5243 HGNC:40|MIM:171050|Ensembl:ENSG00000085563|HPRD:01370|Vega:OTTHUMG00000023393 "ATP-binding cassette, sub-family B (MDR/TAP), member 1" ABCC2 Human FOXO1;FOXO3 up qRT-PCR;Western blotting; Luciferase Reporter Assay EMSA;Luciferase Reporter Assay+Deletion Multidrug resistance mrp-2;mrp-1 "23763570 " 1244 HGNC:53|MIM:601107|Ensembl:ENSG00000023839|HPRD:03065|Vega:OTTHUMG00000018895 "ATP-binding cassette, sub-family C (CFTR/MRP), member 2" Ac76E Drosophila melanogaster dFOXO up qRT-PCR;Microarray ChIP Stress risisitance acy-2 "19651894 " 40180 FLYBASE:FBgn0004852 Adenylyl cyclase 76E ACO2 Human FOXO3 up qRT-PCR ChIP Metablism aco-2 "21915097 " 50 HGNC:118|MIM:100850|Ensembl:ENSG00000100412|HPRD:00012|Vega:OTTHUMG00000030544 "aconitase 2, mitochondrial" Acta2 Rat FOXO4 down Luciferase Reporter Assay;qRT_PCR;Western blotting ChIP Smooth muscle contractile "16054032 " 81633 RGD:621676 smooth muscle alpha-actin Adipoq Mouse FOXO1 up qRT-PCR;Western blotting;Luciferase Reporter Assay Luciferase Reporter Assay+mutation;EMSA;supershift assays Metabolism col-172;col-181 "17090532 " 11450 MGI:106675|Ensembl:ENSMUSG00000022878|Vega:OTTMUSG00000035780 "adiponectin, C1Q and collagen domain containing" Adm Mouse FOXO up Micoroarray;qRT-PCR ChIP Angiogenesis "17254969 " 11535 MGI:108058|Ensembl:ENSMUSG00000030790 adrenomedullin Agrp Rat FOXO1 up Luciferase Reporter Assay EMSA;Luciferase Reporter Assay;ChIP Metabolism "16604086 " 25582 RGD:2068 agouti related protein homolog (mouse) APOC3 Human FOXO1 up qRT-PCR;Luciferase Reporter Assay Luciferase Reporter Assay+mutation;EMSA;ChIP Metabolism "15546000 " 345 HGNC:610|MIM:107720|Ensembl:ENSG00000110245|HPRD:00132|Vega:OTTHUMG00000046115 apolipoprotein C-III asns-2 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- asns-2 20706209 181121 WormBase:WBGene00019730 hypothetical protein Aspn Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis "23059819 " 306805 RGD:1549776|Ensembl:ENSRNOG00000015410 asporin Atg12 Mouse FOXO3 up qRT-PCR ChIP Autophage lgg-3 "18054316 " 67526 MGI:1914776|Ensembl:ENSMUSG00000032905 autophagy-related 12 (yeast) Atg12 Rat FOXO1;FOXO3 up qRT-PCR ChIP Autophagy lgg-3 "19696026 " 361321 RGD:1306306|Ensembl:ENSRNOG00000000157 ATG12 autophagy related 12 homolog (S. cerevisiae) ATG14 Human FOXO1;FOXO3 up qRT-PCR; Luciferase Reporter Assay ChIP Autophage "22992773 " 22863 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 ATG14 autophagy related 14 homolog (S. cerevisiae) att-ORFA Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- F43G9.3 "18177722 " 42429 FLYBASE:FBgn0067783 alternative testis transcripts open reading frame A BBC3 Human FOXO1;FOXO3 up Western blotting; qRT-PCR ChIP Apoptosis "23532334 " 27113 HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165 BCL2 binding component 3 Bbc3 Mouse FOXO3 up qRT-PCR;Western blotting;Luciferase Reporter Assay Luciferase Reporter Assay+Mutation; ChIP Apotopsis "16801400 " 170770 MGI:2181667|Ensembl:ENSMUSG00000002083|Vega:OTTMUSG00000022267 BCL2 binding component 3 Bbc3 Rat FOXO3 up qRT-PCR ChIP Cell cycle "21835778 " 317673 RGD:631434 Bcl-2 binding component 3 BCL10 Human FOXO3 up qRT-PCR; Western blotting ChIP+EMSA+Mutation Apoptosis "22474286 " 8915 HGNC:989|MIM:603517|Ensembl:ENSG00000142867|HPRD:04625|Vega:OTTHUMG00000009965 B-cell CLL/lymphoma 10 BCL2L11 Human FOXO3 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay Apoapoptosis "17626006 " 10018 HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 BCL2-like 11 (apoptosis facilitator) BCL2L11 Human FOXO4 up Luciferase Reporter Assay; Western blotting ChIP; Luciferase Reporter Assay Apopoptosis "15824087 " 10018 HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 BCL2-like 11 (apoptosis facilitator) BCL2L11 Human FOXO3 up Luciferase Reporter Assay;Western blotting ChIP; Luciferase Reporter Assay+Mutation Apopoptosis "15688014 " 10018 HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 BCL2-like 11 (apoptosis facilitator) BCL2L11 Human FOXO3 up Western blotting; Luciferase Reporter Assay Luciferase Reporter assay+Mutation Apoptosis "14527951 " 10018 HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 BCL2-like 11 (apoptosis facilitator) Bcl2l11 Mouse FOXO3 up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Apotopsis "17702754 " 12125 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 BCL2-like 11 (apoptosis facilitator) Bcl2l11 Mouse FOXO3 up qRT-PCR; Luciferase Reporter Assay EMSA;Luciferase Reporter Assay Apoptosis "16373335 " 12125 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 BCL2-like 11 (apoptosis facilitator) Bcl2l11 Rat FOXO1;FOXO3 up qRT-PCR;Western blotting; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Apoptosis "12913110 " 64547 RGD:628774|Ensembl:ENSRNOG00000016551 BCL2-like 11 (apoptosis facilitator) BCL6 Human FOXO3 up Luciferase Reporter Assay; Western blotting;qRT-PCR Luciferase Reporter assay;ChIP Cell cycle "15509806 " 604 HGNC:1001|MIM:109565|Ensembl:ENSG00000113916|HPRD:00180|Vega:OTTHUMG00000156441 B-cell CLL/lymphoma 6 BCL6 Human FOXO4 up TET-On system;Luciferase Reporter Assay Luciferase Reporter assay+Mutation;Gel shift Assay -- "11777915 " 604 HGNC:1001|MIM:109565|Ensembl:ENSG00000113916|HPRD:00180|Vega:OTTHUMG00000156441 B-cell CLL/lymphoma 6 BCL6 Human FOXO3 up Microarray;qRT-PCR ChIP -- "18226221 " 604 HGNC:1001|MIM:109565|Ensembl:ENSG00000113916|HPRD:00180|Vega:OTTHUMG00000156441 B-cell CLL/lymphoma 6 Bcl6 Mouse FOXO1;FOXO3 up Luciferase Reporter Assay ChIP Immunity "22406686 " 12053 MGI:107187|Ensembl:ENSMUSG00000022508|Vega:OTTMUSG00000027148 B cell leukemia/lymphoma 6 bmm Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Metablism C05D11.7 "21565616 " 39611 FLYBASE:FBgn0036449 brummer Bmper Mouse FOXO down Micoroarray;qRT-PCR ChIP -- "17254969 " 73230 MGI:1920480|Ensembl:ENSMUSG00000031963 BMP-binding endothelial regulator BNIP3 Human FOXO3 up Western blotting; Luciferase Reporter Assay ChIP Muscle atrophy dct-1 "18054315 " 664 HGNC:1084|MIM:603293|Ensembl:ENSG00000176171|HPRD:04482|Vega:OTTHUMG00000019278 BCL2/adenovirus E1B 19kDa interacting protein 3 BNIP3 Human FOXO3;FOXO4 up qRT-PCR ChIP -- dct-1 "20733005 " 664 HGNC:1084|MIM:603293|Ensembl:ENSG00000176171|HPRD:04482|Vega:OTTHUMG00000019278 BCL2/adenovirus E1B 19kDa interacting protein 3 BNIP3L Human FOXO3 up qRT-PCR ChIP Cell death dct-1 "19343039 " 665 HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 BCL2/adenovirus E1B 19kDa interacting protein 3-like BTG1 Human FOXO3 up Microarray;qRT-PCR ChIP Cell cycle fog-3 "18226221 " 694 HGNC:1130|MIM:109580|Ensembl:ENSG00000133639|HPRD:15912|Vega:OTTHUMG00000170092 "B-cell translocation gene 1, anti-proliferative" Btg1 Mouse FOXO3 up Microarray;qRT_PCR; Luciferase Reporter Assay Luciferase Reporter assay+Mutation Differentiation fog-3 "14734530 " 12226 MGI:88215|Ensembl:ENSMUSG00000036478 "B cell translocation gene 1, anti-proliferative" C10orf10 Human FOXO1;FOXO3 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation; EMSA -- "21510935 " 11067 HGNC:23355|MIM:611309|Ensembl:ENSG00000165507|HPRD:12558|Vega:OTTHUMG00000018063 chromosome 10 open reading frame 10 C10orf10 Human FOXO1 up Microarray;qRT-PCR;western;Northern blotting ChIP -- "12150827 " 11067 HGNC:23355|MIM:611309|Ensembl:ENSG00000165507|HPRD:12558|Vega:OTTHUMG00000018063 chromosome 10 open reading frame 10 C25E10.8 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- C25E10.8 20706209 182892 WormBase:WBGene00016097 hypothetical protein C33A12.7 C. elegans DAF-16 up Microarray;qRT-PCR DamID Stress Resistance C33A12.7 20706209 177783 WormBase:WBGene00007886 hypothetical protein CAT Human FOXO3 up qRT-PCR;Western blotting ChIP Anti-oxidation ctl-2;ctl-1;ctl-3 "19324885 " 847 HGNC:1516|MIM:115500|Ensembl:ENSG00000121691|HPRD:00282|Vega:OTTHUMG00000044353 catalase Cat Rat FOXO3 Up Luciferase Reporter Assay Luciferase Reporter Assay Stress resisitance ctl-2;ctl-1;ctl-3 "11884717 " 24248 RGD:2279|Ensembl:ENSRNOG00000008364 catalase CAV1 Human FOXO3;FOXO4 up Microarray;Western blotting ChIP; Luciferase Reporter Assay Signaling cav-1 "15458387 " 857 HGNC:1527|MIM:601047|Ensembl:ENSG00000105974|HPRD:03028|Vega:OTTHUMG00000023413 "caveolin 1, caveolae protein, 22kDa" CAV1 Human FOXO1 up Luciferase Reporter Assay ChIP Tumor suppression cav-1 "18444242 " 857 HGNC:1527|MIM:601047|Ensembl:ENSG00000105974|HPRD:03028|Vega:OTTHUMG00000023413 "caveolin 1, caveolae protein, 22kDa" ccch-1 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- ccch-1 20706209 179584 WormBase:WBGene00009532 CCCH-type zinc finger transcription factor CCND1 Human FOXO1 down Luciferase Reporter Assay;Western blotting Luciferase Reporter Assay;ChIP Cell cycle cyd-1 "22266855 " 595 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 cyclin D1 CCND1 Human FOXO1 down Microarray;qRT-PCR ChIP Cell cycle cyd-1 "12150827 " 595 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 cyclin D1 CCND2 Human FOXO3 up qRT-PCR ChIP Cell cycle cyd-1 "20733005 " 894 HGNC:1583|MIM:123833|Ensembl:ENSG00000118971|HPRD:00451|Vega:OTTHUMG00000168123 cyclin D2 Ccnd2 Mouse FOXO3 down Western blotting ChIP Cell cycle cyd-1 "15241468 " 12444 MGI:88314|Ensembl:ENSMUSG00000000184 cyclin D2 Ccnd2 Rat FOXO1 down Western blotting; qRT-PCR ChIP; Luciferase Reporter Assay Cell cycle cyd-1 "15613482 " 64033 RGD:621083|Ensembl:ENSRNOG00000019939 cyclin D2 CCNG2 Human FOXO3 up Luciferase Reporter Assay;Western blotting Luciferase Reporter Assay+Mutation; ChIP Ovarian cancer cell line OV2008 cells R02F2.1 "21532621 " 901 HGNC:1593|MIM:603203|Ensembl:ENSG00000138764|HPRD:04438|Vega:OTTHUMG00000130100 cyclin G2 CCNG2 Human FOXO1;FOXO3 up Western blotting ChIP Cell cycle R02F2.1 "21873430 " 901 HGNC:1593|MIM:603203|Ensembl:ENSG00000138764|HPRD:04438|Vega:OTTHUMG00000130100 cyclin G2 CCNG2 Human FOXO3 up Microarray;qRT-PCR ChIP Cell cycle R02F2.1 "18226221 " 901 HGNC:1593|MIM:603203|Ensembl:ENSG00000138764|HPRD:04438|Vega:OTTHUMG00000130100 cyclin G2 CCNG2 Human FOXO1 up Microarray;qRT-PCR ChIP Cell cycle R02F2.1 "12150827 " 901 HGNC:1593|MIM:603203|Ensembl:ENSG00000138764|HPRD:04438|Vega:OTTHUMG00000130100 cyclin G2 Ccng2 Mouse FOXO1;FOXO3 up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay;EMSA Cell cycle R02F2.1 "16493026 " 12452 MGI:1095734|Ensembl:ENSMUSG00000029385|Vega:OTTMUSG00000026614 cyclin G2 Ccng2 Mouse FOXO3;FOXO4 up Northern blotting EMSA;ChIP Cell cycle R02F2.1 "14966295 " 12452 MGI:1095734|Ensembl:ENSMUSG00000029385|Vega:OTTMUSG00000026614 cyclin G2 Ccng2 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis R02F2.1 "23059819 " 29157 RGD:1305002|Ensembl:ENSRNOG00000002089 cyclin G2 Ccr7 Mouse FOXO1 up microarray;qRT-PCR ChIP-qPCR -- "23733882 " 12775 MGI:103011|Ensembl:ENSMUSG00000037944|Vega:OTTMUSG00000006448 chemokine (C-C motif) receptor 7 Ccrn4l Mouse FOXO up Micoroarray;qRT-PCR ChIP -- "17254969 " 12457 MGI:109382|Ensembl:ENSMUSG00000023087|Vega:OTTMUSG00000027519 CCR4 carbon catabolite repression 4-like (S. cerevisiae) CDKN1A Human FOXO3 up qRT-PCR ChIP Cell cycle "19343039 " 1026 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 "cyclin-dependent kinase inhibitor 1A (p21, Cip1)" CDKN1A Human FOXO1; FOXO3 ; FOXO4 up Luciferase Reporter Assay; Northern blotting Luciferase Reporter Assay+Mutation;EMSA Cell cycle "15084259 " 1026 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 "cyclin-dependent kinase inhibitor 1A (p21, Cip1)" Cdkn1a Mouse FOXO1 up qRT-PCR ChIP Cell cycle "18218983 " 12575 MGI:104556|Ensembl:ENSMUSG00000023067|Vega:OTTMUSG00000031654 cyclin-dependent kinase inhibitor 1A (P21) Cdkn1a Mouse FOXO1 up Lucicerase Reporter Assay;Western blotting; Northern blotting Luciferase Reporter Assay+Mutation; EMSA;ChIP Cell Cycle "12530968 " 12575 MGI:104556|Ensembl:ENSMUSG00000023067|Vega:OTTMUSG00000031654 cyclin-dependent kinase inhibitor 1A (P21) CDKN1B Human FOXO up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Cell cycle cki-1;cki-2 "15798096 " 1027 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 "cyclin-dependent kinase inhibitor 1B (p27, Kip1)" CDKN1B Human FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Cell cycle cki-1;cki-2 "20661471 " 1027 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 "cyclin-dependent kinase inhibitor 1B (p27, Kip1)" Cdkn1b Rat FOXO1 up qRT-PCR;Western blotting ChIP Cell cycle cki-1;cki-2 "17408630 " 83571 RGD:69062|Ensembl:ENSRNOG00000007249 cyclin-dependent kinase inhibitor 1B Cdkn1b Rat FOXO1;FOXO3 up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Cell cycle cki-1;cki-2 "18787071 " 83571 RGD:69062|Ensembl:ENSRNOG00000007249 cyclin-dependent kinase inhibitor 1B Cdkn2a Mouse FOXO3 up Luciferase Reporter Assay;qRT_PCR;Western blotting ChIP Cell cycle "17974917 " 12578 MGI:104738|Ensembl:ENSMUSG00000044303|Vega:OTTMUSG00000007706 cyclin-dependent kinase inhibitor 2A CDKN2B Human FOXO1;FOXO3 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation; EMSA Cell cycle "17873901 " 1030 HGNC:1788|MIM:600431|Ensembl:ENSG00000147883|HPRD:02696|Vega:OTTHUMG00000019691 "cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)" CDKN2D Human FOXO1;FOXO3 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation; EMSA Cell cycle "17873901 " 1032 HGNC:1790|MIM:600927|Ensembl:ENSG00000129355|HPRD:02957 "cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)" Cebpb Mouse FOXO1 up qRT-PCR;Western blotting;Luciferase Reproter Assay Luciferase Reporter Assay+mutation;avidin-biotin-conjugated DNA precipitation (ABCD) assay;ChIP Inflammation "19026986 " 12608 MGI:88373|Ensembl:ENSMUSG00000056501|Vega:OTTMUSG00000016307 "CCAAT/enhancer binding protein (C/EBP), beta" CG10924 Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- pck-2;pck-1 "18177722 " 37130 FLYBASE:FBgn0034356 CG10924 gene product from transcript CG10924-RA CG13624 Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- "18177722 " 42930 FLYBASE:FBgn0039209 CG13624 gene product from transcript CG13624-RD CG32193 Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- "18177722 " 317905 FLYBASE:FBgn0052193 CHES-1-like Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- fkh-7 "18177722 " 31678 FLYBASE:FBgn0029504 Checkpoint suppressor homologue Cited2 Mouse FOXO up Micoroarray;qRT-PCR ChIP Apoptosis "17254969 " 17684 MGI:1306784|Ensembl:ENSMUSG00000039910 "Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2" Cited2 Mouse FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis "21159781 " 17684 MGI:1306784|Ensembl:ENSMUSG00000039910 "Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2" Cited2 Mouse FOXO3 up qRT-PCR ChIP Apoptosis "18158893 " 17684 MGI:1306784|Ensembl:ENSMUSG00000039910 "Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2" coq-1 C. elegans DAF-16 up Microarray;qRT-PCR DamID Stress Resistance coq-1 20706209 172190 WormBase:WBGene00000761 COenzyme Q (ubiquinone) biosynthesis Ctgf Mouse FOXO up Micoroarray;qRT-PCR ChIP Angiogenesis "17254969 " 14219 MGI:95537|Ensembl:ENSMUSG00000019997|Vega:OTTMUSG00000019709 connective tissue growth factor Ctla4 Mouse FOXO1 up Flow cytometry ChIP Imuniity "21167754 " 12477 MGI:88556|Ensembl:ENSMUSG00000026011|Vega:OTTMUSG00000002278 cytotoxic T-lymphocyte-associated protein 4 CYP19A1 Human FOXO1;FOXO4 up Luciferase Reporter Assay Luciferase Reporter Assay+Deletion Aromatase (CYP19A1) catalyzes the conversion of androgens to estrogens "22197207 " 1588 HGNC:2594|MIM:107910|Ensembl:ENSG00000137869|HPRD:00488|Vega:OTTHUMG00000131747 "cytochrome P450, family 19, subfamily A, polypeptide 1" cyp-35B1 C. elegans DAF-16 up qRT-PCR cyp-35B1:GFP Reporter+Deletion;Yeast 1-hybrid Assays -- dod-13 "21408062 " 178803 WormBase:WBGene00019472 CYtochrome P450 family CYR61 Human FOXO3 down Western blotting ChIP Inflammatory "23239110 " 3491 HGNC:2654|MIM:602369|Ensembl:ENSG00000142871|HPRD:09089|Vega:OTTHUMG00000010577 "cysteine-rich, angiogenic inducer, 61" DDIT3 Human FOXO3 up Microarray;qRT-PCR ChIP Apoptosis "18226221 " 1649 HGNC:2726|MIM:126337|Ensembl:ENSG00000175197|HPRD:00529|Vega:OTTHUMG00000170046 DNA-damage-inducible transcript 3 Ddit4 Mouse FOXO up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Growth "18299344 " 74747 MGI:1921997|Ensembl:ENSMUSG00000020108 DNA-damage-inducible transcript 4 Dgka Mouse FOXO1;FOXO3 up Luciferase Reporter Assay ChIP Immune response regulation dgk-3 "22890845 " 13139 MGI:102952|Ensembl:ENSMUSG00000025357 "diacylglycerol kinase, alpha" DLP Drosophila melanogaster dFOXO up Western blotting Luciferase Reporter Assay+Mutation Oxidative stress response "23593018 " 33906 FLYBASE:FBgn0031820 Daxx-like protein dm Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay;Microarray ChIP Cell proliferation "18177722 " 31310 FLYBASE:FBgn0000472 diminutive DnaJ-1 Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Proteostasis "21111239 " 38643 FLYBASE:FBgn0015657 DnaJ-like-1 dod-17 C. elegans DAF-16 down Microarray;confirmed by RFP ChIP -- dod-17 "23312285 " 187266 WormBase:WBGene00010745 Downstream Of DAF-16 (regulated by DAF-16) dor Drosophila melanogaster dFOXO up qRT-PCR ChIP Metabolism "20888228 " 31118 FLYBASE:FBgn0000482 deep orange Drs Drosophila melanogaster dFOXO up GFP;Luciferase Luciferase Reporter Assay+Mutation;EMSA -- "20090753 " 38419 FLYBASE:FBgn0010381 Drosomycin EDN1 Human FOXO up Western blotting; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation Vasoconstrictor "19887561 " 1906 HGNC:3176|MIM:131240|Ensembl:ENSG00000078401|HPRD:07030|Vega:OTTHUMG00000014266 endothelin 1 Eomes Mouse FOXO1 up Western blotting and qRT-PCR ChIP Differentiation tbx-37;tbx-38 "22425248 " 13813 MGI:1201683|Ensembl:ENSMUSG00000032446|Vega:OTTMUSG00000021058 eomesodermin homolog (Xenopus laevis) ERBB3 Human FoxO1; FOXO3 ; FOXO4 up Western blotting ChIP Signaling "21215704 " 2065 HGNC:3431|MIM:190151|Ensembl:ENSG00000065361|HPRD:01820|Vega:OTTHUMG00000170140 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Esr1 Mouse FOXO3 up Western;Luciferase Reporter Assay; Luciferase Reporter Assay;EMSA;ChIP;CAT reporter assay+mutation Tumor suppression "15367686 " 13982 MGI:1352467|Ensembl:ENSMUSG00000019768|Vega:OTTMUSG00000020886 estrogen receptor 1 (alpha) FAM65B Human FOXO1 up qRT-PCR;Luciferase Reporter Assay ChIP immune C27H2.2 "23241886 " 9750 HGNC:13872|MIM:611410|Ensembl:ENSG00000111913|HPRD:12881|Vega:OTTHUMG00000014375 "family with sequence similarity 65, member B" Fasl Mouse FOXO1 up Western blotting EMSA Apoptosis "17662023 " 14103 MGI:99255|Ensembl:ENSMUSG00000000817 "Fas ligand (TNF superfamily, member 6)" FASLG Mongolian gerbils FoxO1; FoxO3 ; FoxO4 up Western blotting EMSA Apoptosis "12172378 " Faslg Rat FOXO1 up qRT¨CPCR;Luciferase Reporter Assay EMSA;Luciferase Reporter Assay+Mutation Apoptosis "14576824 " 25385 RGD:3880|Ensembl:ENSRNOG00000002978 "Fas ligand (TNF superfamily, member 6)" FBXO32 Human FOXO1;FOXO3 up Western blotting ChIP Cell cycle mfb-1 "21873430 " 114907 HGNC:16731|MIM:606604|Ensembl:ENSG00000156804|HPRD:05966|Vega:OTTHUMG00000164981 F-box protein 32 Fbxo32 Mouse FOXO3 up Luciferase Reporter Assay ChIP Apoptosis mfb-1 "17053067 " 67731 MGI:1914981|Ensembl:ENSMUSG00000022358 F-box protein 32 Fbxo32 Mouse FOXO1;FOXO3 up Northern blotting; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Apoptosis mfb-1 "15109499 " 67731 MGI:1914981|Ensembl:ENSMUSG00000022358 F-box protein 32 Fbxo32 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis mfb-1 "23059819 " 171043 RGD:620373|Ensembl:ENSRNOG00000006738 F-box protein 32 Fbxo32 Rat FOXO3 up qRT-PCR Luciferase Reporter Assay Apoptosis mfb-1 "15781459 " 171043 RGD:620373|Ensembl:ENSRNOG00000006738 F-box protein 32 Flcn Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis flcn-1 "23059819 " 303185 RGD:735088|Ensembl:ENSRNOG00000003302 folliculin FOXO1 Human FOXO1;FOXO3 up qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Signaling daf-16 "19244250 " 2308 HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 forkhead box O1 FOXO1 Human FOXO3 up Luciferase Reporter Assay;qRT-PCR Luciferase Reporter assay;ChIP -- daf-16 "22931788 " 2308 HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 forkhead box O1 Foxo1 Rat FOXO1;FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation -- daf-16 "19690465 " 84482 RGD:620283 forkhead box O1 FOXP3 Human FOXO3 up Fluorescence-activated cell sorting FACS analysis; Luciferase Luciferase Reporter Assay+Mutation; ChIP Immunity "20439537 " 50943 HGNC:6106|MIM:300292|Ensembl:ENSG00000049768|HPRD:02242|Vega:OTTHUMG00000024135 forkhead box P3 Foxp3 Mouse FOXO1;FOXO3 up qRT-PCR;Western blotting; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation; ChIP Immunity "20467422 " 20371 MGI:1891436|Ensembl:ENSMUSG00000039521|Vega:OTTMUSG00000016624 forkhead box P3 G6PC Human FOXO1; FOXO3 ; FOXO6 up Luciferase Reporter Assay Mutation;Luciferase Reporter Assay Metablism "15987244 " 2538 HGNC:4056|MIM:613742|Ensembl:ENSG00000131482|HPRD:01983 "glucose-6-phosphatase, catalytic subunit" G6PC Human FOXO4 up SEAP Reporter EMSA;SEAP Reporter Metabolism "11779849 " 2538 HGNC:4056|MIM:613742|Ensembl:ENSG00000131482|HPRD:01983 "glucose-6-phosphatase, catalytic subunit" G6PC Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;ChIP Metablism "12556524 " 2538 HGNC:4056|MIM:613742|Ensembl:ENSG00000131482|HPRD:01983 "glucose-6-phosphatase, catalytic subunit" G6PC Human FOXO1;FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Metablism "16840535 " 2538 HGNC:4056|MIM:613742|Ensembl:ENSG00000131482|HPRD:01983 "glucose-6-phosphatase, catalytic subunit" G6pc Human FOXO1 up CAT activity assay CAT Activity Assay+Deletion Metabolism "10480625 " 2538 HGNC:4056|MIM:613742|Ensembl:ENSG00000131482|HPRD:01983 "glucose-6-phosphatase, catalytic subunit" GABARAPL1 Human FOXO3 up qRT-PCR ChIP Autophagy lgg-1 "19343039 " 23710 HGNC:4068|MIM:607420|Ensembl:ENSG00000139112|HPRD:07601|Vega:OTTHUMG00000168411 GABA(A) receptor-associated protein like 1 Gabarapl1 Mouse FOXO3 up qRT-PCR ChIP Autophage lgg-1 "18054316 " 57436 MGI:1914980|Ensembl:ENSMUSG00000030161 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 Gabarapl1 Rat FOXO1;FOXO3 up qRT-PCR ChIP Autophagy lgg-1 "19696026 " 689161 RGD:1596143|Ensembl:ENSRNOG00000008498 GABA(A) receptor-associated protein like 1 Gadd45 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis "23059819 " 25112 RGD:2654|Ensembl:ENSRNOG00000005615 "growth arrest and DNA-damage-inducible, alpha" Gadd45 Rat FOXO3 up qRT-PCR ChIP Cell cycle "21835778 " 25112 RGD:2654|Ensembl:ENSRNOG00000005615 "growth arrest and DNA-damage-inducible, alpha" Gadd45 Rat FOXO3 up qRT-PCR;Western blotting;Luciferase Reporter Assay Luciferase Reporter Assay+Mutation DNA repair "11964479 " 25112 RGD:2654|Ensembl:ENSRNOG00000005615 "growth arrest and DNA-damage-inducible, alpha" GADD45A Human FOXO3 up qRT-PCR ChIP Cell cycle and cell death "19343039 " 1647 HGNC:4095|MIM:126335|Ensembl:ENSG00000116717|HPRD:00528|Vega:OTTHUMG00000009374 "growth arrest and DNA-damage-inducible, alpha" Gadd45a Mouse FOXO4 up Luciferase Reporter Assay;Northern blotting;Western blotting Luciferase Reporter assay+Mutation Cell cycle "12048180 " 13197 MGI:107799|Ensembl:ENSMUSG00000036390|Vega:OTTMUSG00000023157 growth arrest and DNA-damage-inducible 45 alpha Gk Rat FOXO1 down qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation; EMSA Metbolism R11F4.1 "19740748 " 79223 RGD:70893|Ensembl:ENSRNOG00000034116 glycerol kinase gln-3 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- gln-3 20706209 178452 WormBase:WBGene00001604 GLutamiNe synthetase (glutamate-ammonia ligase) Glul Mouse FOXO3;FOXO4 up qRT-PCR ChIP Metablism gln-3 "22820375 " 14645 MGI:95739|Ensembl:ENSMUSG00000026473|Vega:OTTMUSG00000016462 glutamate-ammonia ligase (glutamine synthetase) gpd-2 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Metabolic, glyceraldehyde-3-phosphate dehydrogenase" gpd-2 "23312285 " 3565504 WormBase:WBGene00001684 GPD (glyceraldehyde 3-phosphate dehydrogenase) H18N23.2 C. elegans DAF-16 up Microarray;qRT-PCR DamID Signalling H18N23.2 20706209 181788 WormBase:WBGene00019211 hypothetical protein Hbp1 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis "23059819 " 27080 RGD:620444|Ensembl:ENSRNOG00000008927 HMG-box transcription factor 1 hgo-1 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Stress response, homogentisate 1,2-dioxygenase" hgo-1 "23312285 " 172726 WormBase:WBGene00001843 HomoGentisate Oxidase hlh-13 C. elegans DAF-16 up qRT-PCR ChIP "Recovery from L1 arrest and IIS-dependent dauer diapause, and moderate resistance to starvation stress, but not lifespan, heat, or oxidative stress" hlh-13 "19103192 " 185980 WormBase:WBGene00001957 Helix Loop Helix HMGCS2 Human FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA;ChIP -- hmgs-1 "12027802 " 3158 HGNC:5008|MIM:600234|Ensembl:ENSG00000134240|HPRD:02580|Vega:OTTHUMG00000012101 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) Hoxc5 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis ceh-16 "23059819 " 315341 RGD:1307584|Ensembl:ENSRNOG00000016598 homeo box C5 hsp-12.6 C. elegans DAF-16 up Microarray;confirmed by RFP ChIP "Stress response, small heat shock protein" hsp-12.6? "23312285 " 177778 WormBase:WBGene00002013 Heat Shock Protein Hsp70Bbb Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Proteostasis "21111239 " 50022 FLYBASE:FBgn0051354 CG5834 gene product from transcript CG5834-RA Hsp83 Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Proteostasis daf-21 "21111239 " 38389 FLYBASE:FBgn0001233 Heat shock protein 83 ICAM1 Human FOXO1 up qRT-PCR ChIP Cell adhesion "22405072 " 3383 HGNC:5344|MIM:147840|Ensembl:ENSG00000090339|HPRD:00996 intercellular adhesion molecule 1 ID1 Human FOXO3 down Micoroarray;qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation Differentiation "17132628 " 3397 HGNC:5360|MIM:600349|Ensembl:ENSG00000125968|HPRD:08980|Vega:OTTHUMG00000032181 "inhibitor of DNA binding 1, dominant negative helix-loop-helix protein" IGF1 Human FOXO1 down Luciferase Reporter Assay ChIP Signaling "23152492 " 3479 HGNC:5464|MIM:147440|Ensembl:ENSG00000017427|HPRD:00936|Vega:OTTHUMG00000149910 insulin-like growth factor 1 (somatomedin C) IGF1R Human FoxO1; FOXO3 ; FOXO4 up Western blotting ChIP Metablism daf-2 "21215704 " 3480 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 insulin-like growth factor 1 receptor IGFBP1 Human FOXO1 up Microarray;qRT-PCR;Western blotting ChIP -- "12150827 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up qRT-PCR;Western blotting; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation Apoptosis "20123982 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up CAT activity assay EMSA;CAT Reporter assay;Southwestern blotting Insulin-like growth factor binding protein "10385407 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO4 up SEAP Reporter EMSA;SEAP Reporter Insulin-like growth factor binding protein "11779849 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Insulin-like growth factor binding protein "10358076 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Insulin-like growth factor binding protein "10358014 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up CAT activity assay CAT activity assay+Mutation Insulin-like growth factor binding protein "12556524 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 IGFBP1 Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Insulin-like growth factor binding protein "12493691 " 3484 HGNC:5469|MIM:146730|Ensembl:ENSG00000146678|HPRD:00897|Vega:OTTHUMG00000152343 insulin-like growth factor binding protein 1 Igfbp1 Rat FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Metabolism "11445561 " 25685 RGD:2872|Ensembl:ENSRNOG00000008371 insulin-like growth factor binding protein 1 Igfbp1 Rat FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Metbolism "10913147 " 25685 RGD:2872|Ensembl:ENSRNOG00000008371 insulin-like growth factor binding protein 1 Il1b Mouse FOXO1 up qRT-PCR Luciferase Reporter Assay+mutation;ChIP Inflammation "19651810 " 16176 MGI:96543|Ensembl:ENSMUSG00000027398|Vega:OTTMUSG00000015509 interleukin 1 beta Il7r Mouse FOXO1 up Fluorescence-activated cell sorting FACS ChIP Immunity "19285438 " 16197 MGI:96562|Ensembl:ENSMUSG00000003882 interleukin 7 receptor Il7r Mouse FOXO1 up qTR-PCR ChIP Immunity "19136962 " 16197 MGI:96562|Ensembl:ENSMUSG00000003882 interleukin 7 receptor Il7r Mouse FOXO1 up microarray;qRT-PCR ChIP-qPCR -- "23733882 " 16197 MGI:96562|Ensembl:ENSMUSG00000003882 interleukin 7 receptor Ilp6 Drosophila melanogaster dFOXO up qRT-PCR ChIP Growth "20059956 " 31220 FLYBASE:FBgn0044047 Insulin-like peptide 6 InR Drosophila melanogaster dFOXO up qRT-PCR;Western blotting ChIP Metabolism daf-2 "16230533 " 42549 FLYBASE:FBgn0013984 Insulin-like receptor InR Drosophila melanogaster dFOXO up Microarray;RNase protection assay;Luciferase Reporter Assay EMSA;ChIP -- daf-2 "12893776 " 42549 FLYBASE:FBgn0013984 Insulin-like receptor INSR Human FOXO1 up Luciferase Reporter Assay; qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation Signaling daf-2 "16230533 " 3643 HGNC:6091|MIM:147670|Ensembl:ENSG00000171105|HPRD:00975 insulin receptor INSR Human FoxO1; FOXO3 ; FOXO4 up Western blotting ChIP Signaling daf-2 "21215704 " 3643 HGNC:6091|MIM:147670|Ensembl:ENSG00000171105|HPRD:00975 insulin receptor IRS1 Human FOXO1 up qRT-PCR ChIP Metablism "22405072 " 3667 HGNC:6125|MIM:147545|Ensembl:ENSG00000169047|HPRD:00943|Vega:OTTHUMG00000133179 insulin receptor substrate 1 IRS2 Human FOXO1;FOXO3 up qRT-PCR ChIP Metablism "21933986 " 8660 HGNC:6126|MIM:600797|Ensembl:ENSG00000185950|HPRD:02878|Vega:OTTHUMG00000017338 insulin receptor substrate 2 IRS2 Human FOXO1;FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay;EMSA;ChIP Signaling "15048126 " 8660 HGNC:6126|MIM:600797|Ensembl:ENSG00000185950|HPRD:02878|Vega:OTTHUMG00000017338 insulin receptor substrate 2 Kcnj8 Mouse FOXO1;FOXO3 up Western blotting ;qRT-PCR EMSA Subunit of ATP-dependent potassium channels "18202312 " 16523 MGI:1100508|Ensembl:ENSMUSG00000030247 "potassium inwardly-rectifying channel, subfamily J, member 8" KLF2 Human FOXO1 up qRT-PCR;Western blotting EMSA;ChIP Immunity mua-1 "18713968 " 10365 HGNC:6347|MIM:602016|Ensembl:ENSG00000127528|HPRD:03602 Kruppel-like factor 2 (lung) KLF6 Human FOXO3 up Microarray;qRT-PCR ChIP -- "18226221 " 1316 HGNC:2235|MIM:602053|Ensembl:ENSG00000067082|HPRD:03632|Vega:OTTHUMG00000017567 Kruppel-like factor 6 LARS2 Human FOXO3 up qRT-PCR ChIP Metablism lrs-2 "21915097 " 23395 HGNC:17095|MIM:604544|Ensembl:ENSG00000011376|HPRD:05178|Vega:OTTHUMG00000133177 "leucyl-tRNA synthetase 2, mitochondrial" Lifr Mouse FOXO3 up qRT-PCR ChIP Signaling "18258752 " 16880 MGI:96788|Ensembl:ENSMUSG00000054263 leukemia inhibitory factor receptor Lip4 Drosophila melanogaster dFOXO up qRT-PCR ChIP; Luciferase Reporter Assay;EMSA Metabolism "18234213 " 34450 FLYBASE:FBgn0032264 Lipase 4 Lk6 Drosophila melanogaster dFOXO up qRT-PCR; Luciferase Reporter Assay; Microarray ChIP Protein synthesis "18177722 " 44672 FLYBASE:FBgn0017581 CG17342 gene product from transcript CG17342-RA Mafa Mouse FOXO1 up Western blotting; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay -- "16154098 " 378435 MGI:2673307|Ensembl:ENSMUSG00000047591 "v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)" mai-1 C. elegans DAF-16 up Microarray;qRT-PCR DamID Metabolism mai-1 20706209 3565232 WormBase:WBGene00003124 Mitochondrial ATPase Inhibitor family MAP1LC3A Human FOXO3 up qRT-PCR ChIP Autophagy lgg-2 "19343039 " 84557 HGNC:6838|MIM:601242|Ensembl:ENSG00000101460|HPRD:03144|Vega:OTTHUMG00000032306 microtubule-associated protein 1 light chain 3 alpha Map1lc3b Mouse FOXO3 up qRT-PCR ChIP Autophage lgg-2 "18054316 " 67443 MGI:1914693|Ensembl:ENSMUSG00000031812 microtubule-associated protein 1 light chain 3 beta Map1lc3b Mouse FOXO3 up Western blotting; Luciferase Reporter Assay Luciferase Reporter Assay+Mutation; ChIP Muscle atrophy lgg-2 "18054315 " 67443 MGI:1914693|Ensembl:ENSMUSG00000031812 microtubule-associated protein 1 light chain 3 beta Mcm7 Mouse FOXO3 up qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Cell proliferation and differentiation mcm-7 "21386132 " 17220 MGI:1298398|Ensembl:ENSMUSG00000029730|Vega:OTTMUSG00000022672 minichromosome maintenance deficient 7 (S. cerevisiae) mdh-1 C. elegans DAF-16 up Microarray;qRT-PCR DamID Metabolism mdh-1 20706209 179041 WormBase:WBGene00018491 hypothetical protein MIR145 Human FOXO1;FOXO3 up qRT-PCR ChIP Tumor suppression "21075312 " 406937 HGNC:31532|MIM:611795|miRBase:MI0000461 microRNA 145 MIR30D Human FOXO3 up qRT-PCR ChIP Apoptosis "23416459 " 407033 HGNC:31628|miRBase:MI0000255 microRNA 30d MMP2 Human FOXO3 up Western blotting; Luciferase Reporter Assay ChIP+Mutation Vascular remodeling "21965295 " 4313 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 "matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)" Mrc1 Mouse FOXO up Micoroarray;qRT-PCR ChIP -- "17254969 " 17533 MGI:97142|Ensembl:ENSMUSG00000026712|Vega:OTTMUSG00000011409 "mannose receptor, C type 1" MRPL12 Human FOXO3 up qRT-PCR ChIP Metablism mrpl-12 "21915097 " 6182 HGNC:10378|MIM:602375|Ensembl:ENSG00000183048|HPRD:03849 mitochondrial ribosomal protein L12 msra-1 C. elegans DAF-16 up qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation Anti-oxidation msra-1 "19747232 " 185709 WormBase:WBGene00018393 hypothetical protein Mstn Mouse FOXO1 up qRT-PCR EMSA;Luciferase Reporter Assay+Deletion Growth and differentiation daf-7 "16885393 " 17700 MGI:95691|Ensembl:ENSMUSG00000026100 myostatin mtl-1 C. elegans DAF-16 up Microarray;confirmed by RFP ChIP "Anti-oxidant, metallothionein-related cadmium-binding" mtl-1 "23312285 " 179060 WormBase:WBGene00003473 MeTaLlothionein MXI1 Human FOXO3 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay+Mutation Signaling "17452451 " 4601 HGNC:7534|MIM:600020|Ensembl:ENSG00000119950|HPRD:02486|Vega:OTTHUMG00000019033 MAX interactor 1 MYOCD Human FOXO3 down qRT-PCR ChIP Differentiation "23554919 " 93649 HGNC:16067|MIM:606127|Ensembl:ENSG00000141052|HPRD:09362|Vega:OTTHUMG00000058767 myocardin MYOCD Monkey FOXO1 up Luciferase Reporter Assay EMSA;Luciferase Reporter Assay+Mutation -- "17021041 " 718193 Ensembl:ENSMMUG00000013281 myocardin-like Myod1 Mouse FOXO3 up Microarray;qRT-PCR Luciferase Reporter Assay+Mutation;EMSA;ChIP Muscle diffeneration hlh-1 "18854138 " 17927 MGI:97275|Ensembl:ENSMUSG00000009471 myogenic differentiation 1 Nampt Mouse FOXO1 up qRT-PCR Luciferase Reporter Assay; ChIP Metabolism "21388966 " 59027 MGI:1929865|Ensembl:ENSMUSG00000020572 nicotinamide phosphoribosyltransferase Neurod1 Mouse FOXO1 up Immunostaining;western EMSA;ChIP;Mutation -- cnd-1 "16154098 " 18012 MGI:1339708|Ensembl:ENSMUSG00000034701|Vega:OTTMUSG00000013310 neurogenic differentiation 1 nnt-1 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Metabolic, nicotinamide nucleotide transhydrogenase" nnt-1 "23312285 " 180884 WormBase:WBGene00003778 Nicotinamide Nucleotide Transhydrogenase NOS3 Human FOXO1;FOXO3 down Microarray;Western blotting ChIP; Luciferase Reporter Assay Angiogenesis "16100571 " 4846 HGNC:7876|MIM:163729|Ensembl:ENSG00000164867|HPRD:01224|Vega:OTTHUMG00000158343 nitric oxide synthase 3 (endothelial cell) NOS3 Human FOXO1;FOXO3 up qRT-PCR and Western blotting EMSA Cardiovascular protection "23583951 " 4846 HGNC:7876|MIM:163729|Ensembl:ENSG00000164867|HPRD:01224|Vega:OTTHUMG00000158343 nitric oxide synthase 3 (endothelial cell) Npy Mouse FOXO1 up GFP;Luciferase Luciferase Reporter assay+Mutation;EMSA;ChIP Metabolism "16783365 " 109648 MGI:97374|Ensembl:ENSMUSG00000029819|Vega:OTTMUSG00000034262 neuropeptide Y NR2C2 Human FOXO3 up Luciferase Reporter Assay;Western blotting and qRT-PCR Luciferase Reporter Assay+Mutation;EMSA;ChIP Stress resisitance nhr-41 "18388194 " 7182 HGNC:7972|MIM:601426|Ensembl:ENSG00000177463|HPRD:03253|Vega:OTTHUMG00000129839 "nuclear receptor subfamily 2, group C, member 2" Oda Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- "18177722 " 36307 FLYBASE:FBgn0014184 Ornithine decarboxylase antizyme OXNAD1 Human FOXO3 up qRT-PCR ChIP Metablism "21915097 " 92106 HGNC:25128|Ensembl:ENSG00000154814|HPRD:14446|Vega:OTTHUMG00000129867 oxidoreductase NAD-binding domain containing 1 Pak1 Rat FOXO1 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay Neuronal polarity pak-1 "20395366 " 29431 RGD:3250|Ensembl:ENSRNOG00000029784 p21 protein (Cdc42/Rac)-activated kinase 1 Pbx1 Mouse FOXO down Micoroarray;qRT-PCR ChIP Endothelial cell homeostasis ceh-20 "17254969 " 18514 MGI:97495|Ensembl:ENSMUSG00000052534 pre B cell leukemia homeobox 1 PCK1 Human FOXO4 up SEAP Reporter EMSA;SEAP Reporter -- pck-2;pck-1 "11779849 " 5105 HGNC:8724|MIM:614168|Ensembl:ENSG00000124253|HPRD:02028|Vega:OTTHUMG00000032825 phosphoenolpyruvate carboxykinase 1 (soluble) Pck1 Mouse FOXO1 up qRT-PCR ChIP Metabolism pck-2;pck-1 "23066095 " 18534 MGI:97501|Ensembl:ENSMUSG00000027513|Vega:OTTMUSG00000016689 "phosphoenolpyruvate carboxykinase 1, cytosolic" Pck1 Mouse FOXO1 up qRT-PCR;Luciferase Reporter Assay ChIP Metabolism pck-2;pck-1 "17627282 " 18534 MGI:97501|Ensembl:ENSMUSG00000027513|Vega:OTTMUSG00000016689 "phosphoenolpyruvate carboxykinase 1, cytosolic" Pck1 Rat FOXO3 up CAT activity assay CAT Activity Assay+Mutation;EMSA Metabolism pck-2;pck-1 "10913147 " 362282 RGD:3267|Ensembl:ENSRNOG00000028616 phosphoenolpyruvate carboxykinase 1 (soluble) Pck1 Rat FOXO1 up Luciferase Reporter Assay Luciferase Reporter assay;Mutation Metabolism pck-2;pck-1 "11445561 " 362282 RGD:3267|Ensembl:ENSRNOG00000028616 phosphoenolpyruvate carboxykinase 1 (soluble) pck-2 C. elegans DAF-16 up Microarray;qRT-PCR DamID Metabolism pck-2 20706209 172556 WormBase:WBGene00011232 hypothetical protein PDGFRA Human FOXO1; FOXO3 ; FOXO4 up Western blotting and qRT-PCR ChIP; Luciferase Reporter Assay Differentiation "22411791 " 5156 HGNC:8803|MIM:173490|Ensembl:ENSG00000134853|HPRD:01429|Vega:OTTHUMG00000128699 "platelet-derived growth factor receptor, alpha polypeptide" pdgy Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- "18177722 " 32426 FLYBASE:FBgn0027601 CG9009 gene product from transcript CG9009-RB pdgy Drosophila melanogaster dFOXO up qRT-PCR ChIP; Luciferase Reporter Assay Metabolism "22275878 " 32426 FLYBASE:FBgn0027601 CG9009 gene product from transcript CG9009-RB PDK4 Human FOXO1;FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA -- pdhk-2 "15047604 " 5166 HGNC:8812|MIM:602527|Ensembl:ENSG00000004799|HPRD:03957|Vega:OTTHUMG00000153977 "pyruvate dehydrogenase kinase, isozyme 4" Pdk4 Mouse FOXO1;FOXO3 up Northern blotting; Luciferase Reporter Assay Luciferase Reporter Assay;EMSA -- pdhk-2 "12820900 " 27273 MGI:1351481|Ensembl:ENSMUSG00000019577|Vega:OTTMUSG00000026853 "pyruvate dehydrogenase kinase, isoenzyme 4" Pdk4 Mouse FOXO1 up qRT-PCR ChIP Metabolism pdhk-2 "23066095 " 27273 MGI:1351481|Ensembl:ENSMUSG00000019577|Vega:OTTMUSG00000026853 "pyruvate dehydrogenase kinase, isoenzyme 4" Pdk4 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis pdhk-2 "23059819 " 89813 RGD:69061|Ensembl:ENSRNOG00000009565 "pyruvate dehydrogenase kinase, isozyme 4" Pdx1 Mouse FOXO1 down qRT-PCR; Luciferase Reproter Assay Luciferase Reporter Assay;Gel Shift Assay Metabolism ceh-16 "12488434 " 18609 MGI:102851|Ensembl:ENSMUSG00000029644|Vega:OTTMUSG00000037552 pancreatic and duodenal homeobox 1 pie-1 C. elegans DAF-16 up qRT-PCR EMSA;ChIP -- pie-1 "19506556 " 176667 WormBase:WBGene00004027 Pharynx and Intestine in Excess PIK3CA Human FOXO3 up qRT-PCR;Western blot ChIP; luciferase Reporter Assay+mutation Signaling age-1 "18644865 " 5290 HGNC:8975|MIM:171834|Ensembl:ENSG00000121879|HPRD:01382|Vega:OTTHUMG00000157311 "phosphoinositide-3-kinase, catalytic, alpha polypeptide" PIK3IP1 Human FOXO3 up Luciferase Reporter Assay EMSA; Luciferase Reporter Assay Apoptosis "22935140 " 113791 HGNC:24942|Ensembl:ENSG00000100100|HPRD:17518|Vega:OTTHUMG00000151256 phosphoinositide-3-kinase interacting protein 1 PINK1 Human FOXO3 up qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation Stress risisitance pink-1 "19276113 " 65018 HGNC:14581|MIM:608309|Ensembl:ENSG00000158828|HPRD:10514|Vega:OTTHUMG00000002841 PTEN induced putative kinase 1 Pink1 Mouse FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis pink-1 "21159781 " 68943 MGI:1916193|Ensembl:ENSMUSG00000028756|Vega:OTTMUSG00000009975 PTEN induced putative kinase 1 Plk1 Mouse FOXO1 up Western blotting ChIP Cell Cycle plk-1;plk-2 "18356527 " 18817 MGI:97621|Ensembl:ENSMUSG00000030867 polo-like kinase 1 (Drosophila) PMAIP1 Human FOXO1 up Western blotting ChIP Apoptosis "21245099 " 5366 HGNC:9108|MIM:604959|Ensembl:ENSG00000141682|HPRD:12002|Vega:OTTHUMG00000132765 phorbol-12-myristate-13-acetate-induced protein 1 Pomc Rat FOXO1 down Luciferase Reporter Assay EMSA;Luciferase Reporter Assay;ChIP Metabolism "16604086 " 24664 RGD:3366|Ensembl:ENSRNOG00000012686 proopiomelanocortin POU5F1 Human FOXO1;FOXO3 up qRT-PCR ChIP; Luciferase Reporter Assay;EMSA Pluripotency of embryonic stem cells "21804543 " 5460 HGNC:9221|MIM:164177|Ensembl:ENSG00000204531|HPRD:01252|Vega:OTTHUMG00000031206 POU class 5 homeobox 1 Pparg Rat FOXO1 down Luciferase Reporter Assay EMSA;ChIP Metabolism nhr-85 "16670091 " 25664 RGD:3371|Ensembl:ENSRNOG00000008839 peroxisome proliferator-activated receptor gamma PPARGC1A Bovine FOXO3 up qRT-PCR;Western blotting ChIP Metabolism "20547753 " 338446 BGD:BT11222|Ensembl:ENSBTAG00000017024 "peroxisome proliferator-activated receptor gamma, coactivator 1 alpha" PPARGC1A Human FOXO3 up qRT-PCR;Western blotting ChIP Anti-oxidation "19324885 " 10891 HGNC:9237|MIM:604517|Ensembl:ENSG00000109819|HPRD:05155|Vega:OTTHUMG00000097747 "peroxisome proliferator-activated receptor gamma, coactivator 1 alpha" PPARGC1A Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter assay+Deletion;ChIP Metbolism "12606503 " 10891 HGNC:9237|MIM:604517|Ensembl:ENSG00000109819|HPRD:05155|Vega:OTTHUMG00000097747 "peroxisome proliferator-activated receptor gamma, coactivator 1 alpha" Ppargc1a Mouse FOXO1 up qRT-PCR ChIP Metabolism "22405073 " 19017 MGI:1342774|Ensembl:ENSMUSG00000029167|Vega:OTTMUSG00000022759 "peroxisome proliferative activated receptor, gamma, coactivator 1 alpha" Ppargc1a Mouse FOXO6 down qTR-PCR ChIP; EMSA Metbolism "23639108 " 19017 MGI:1342774|Ensembl:ENSMUSG00000029167|Vega:OTTMUSG00000022759 "peroxisome proliferative activated receptor, gamma, coactivator 1 alpha" Ppargc1a Mouse FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation Angiogenesis "20547753 " 19017 MGI:1342774|Ensembl:ENSMUSG00000029167|Vega:OTTMUSG00000022759 "peroxisome proliferative activated receptor, gamma, coactivator 1 alpha" PPRC1 Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+deletion;ChIP;ABCD assay+mutation Metabolism "12606503 " 23082 HGNC:30025|Ensembl:ENSG00000148840|HPRD:15173|Vega:OTTHUMG00000018948 "peroxisome proliferator-activated receptor gamma, coactivator-related 1" PRDX3 Human FOXO3 up qRT-PCR;Western blotting ChIP Antioxidation prdx-3 "19324885 " 10935 HGNC:9354|MIM:604769|Ensembl:ENSG00000165672|HPRD:05305|Vega:OTTHUMG00000019146 peroxiredoxin 3 PRDX3 Human FOXO3 up western;qPCR; EMSA+mutation;ChIP Stress resisitance prdx-3 "18195003 " 10935 HGNC:9354|MIM:604769|Ensembl:ENSG00000165672|HPRD:05305|Vega:OTTHUMG00000019146 peroxiredoxin 3 PRDX4 Human FOXO1 down Microarray;qRT-PCR ChIP -- "18301748 " 10549 HGNC:17169|MIM:606506|Ensembl:ENSG00000123131|HPRD:05935|Vega:OTTHUMG00000021253 peroxiredoxin 4 PRDX5 Human FOXO3 up qRT-PCR;Western blotting ChIP Antioxidation "19324885 " 25824 HGNC:9355|MIM:606583|Ensembl:ENSG00000126432|HPRD:05958|Vega:OTTHUMG00000168805 peroxiredoxin 5 PRL Human FOXO1 up Luciferase Reporter Assay Luciferase Reporter assay+Mutation;EMSA -- "11893744 " 5617 HGNC:9445|MIM:176760|Ensembl:ENSG00000172179|HPRD:07180|Vega:OTTHUMG00000016111 prolactin RARS Human FOXO1 up Microarray;qRT-PCR ChIP -- rars-1 "18301748 " 5917 HGNC:9870|MIM:107820|Ensembl:ENSG00000113643|HPRD:00142|Vega:OTTHUMG00000130411 arginyl-tRNA synthetase RBL2 Human FOXO3;FOXO4 up Northern blottingting;Luciferase Reporter Assay Luciferase Reporter assay+Mutation Cell cycle lin-35 "11884591 " 5934 HGNC:9894|MIM:180203|Ensembl:ENSG00000103479|HPRD:01576|Vega:OTTHUMG00000133198 retinoblastoma-like 2 (p130) Rbl2 Mouse FOXO1;FOXO3 up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay;EMSA Cell cycle lin-35 "16493026 " 19651 MGI:105085|Ensembl:ENSMUSG00000031666|Vega:OTTMUSG00000031746 retinoblastoma-like 2 rpn-6 C. elegans DAF-16 up qRT-PCR ChIP(encode project) Aging rpn-6 "22922647 " 175972 WormBase:WBGene00004462 "proteasome Regulatory Particle, Non-ATPase-like" RUNX2 Human FOXO3 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation; ChIP Osteogenesis rnt-1 "21713995 " 860 HGNC:10472|MIM:600211|Ensembl:ENSG00000124813|HPRD:02566|Vega:OTTHUMG00000014774 runt-related transcription factor 2 Scn5a Mouse FOXO1 down Western blotting; qRT-PCR ChIP; Luciferase Reporter Assay -- "22400069 " 20271 MGI:98251|Ensembl:ENSMUSG00000032511|Vega:OTTMUSG00000031832 "sodium channel, voltage-gated, type V, alpha" SCP2 Human FOXO3;FOXO4 up Western blotting;Northern blotting;Luciferase Reporter Assay Luciferase Reporter Assay;FOXO Mutation -- daf-22 "14563822 " 6342 HGNC:10606|MIM:184755|Ensembl:ENSG00000116171|HPRD:01700|Vega:OTTHUMG00000008936 sterol carrier protein 2 scyl Drosophila melanogaster dFOXO up qRT-PCR EMSA Growth "18299344 " 39270 FLYBASE:FBgn0041094 scylla SDC2 Human FOXO3 up qRT-PCR ChIP Apoptosis "22550000 " 6383 HGNC:10659|MIM:142460|Ensembl:ENSG00000169439|HPRD:00803|Vega:OTTHUMG00000164689 syndecan 2 SELL Human FOXO1 up GFP+-gated cell populations GFP+Mutation Immunity "18713968 " 6402 HGNC:10720|MIM:153240|Ensembl:ENSG00000188404|Vega:OTTHUMG00000034809 selectin L SEPP1 Human FOXO1 up qRT-PCR;Western blotting ChIP; Luciferase Reporter Assay Antioxidation "18972406 " 6414 HGNC:10751|MIM:601484|Ensembl:ENSG00000250722|HPRD:03286|Vega:OTTHUMG00000162140 "selenoprotein P, plasma, 1" SEPP1 Human FOXO1 up Luciferase Reporter Assay;qRT_PCR Luciferase Reporter Assay+Mutation Antioxidant "17986386 " 6414 HGNC:10751|MIM:601484|Ensembl:ENSG00000250722|HPRD:03286|Vega:OTTHUMG00000162140 "selenoprotein P, plasma, 1" Serpine1 Rat FOXO1 down CAT activity assay CAT Assay+Deletion;Assay of DNA-Protein Binding by Gel Electrophoresis -- srp-2;srp-3 "11919188 " 24617 RGD:3249|Ensembl:ENSRNOG00000001414 "serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1" SESN3 Human FOXO1 up qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay mTORC1 inhibtion sesn-1 "20412774 " 143686 HGNC:23060|MIM:607768|Ensembl:ENSG00000149212|HPRD:09682|Vega:OTTHUMG00000167829 sestrin 3 Slc37a4 Rat FOXO1 up Luciferase Reporter Assay Luciferase Reporter Assay+Mutation;EMSA Metablism F47B8.10;C42C1.10 "14597389 " 29573 RGD:62066|Ensembl:ENSRNOG00000011361 "solute carrier family 37 (glucose-6-phosphate transporter), member 4" sNPF Drosophila melanogaster FOXO1 up qRT-PCR ChIP Metabolism "22876196 " 35286 FLYBASE:FBgn0032840 short neuropeptide F precursor SOCS3 Human FOXO3 up Luciferase Reporter Assay; qRT-PCR ChIP; Luciferase Reporter Assay Induced in Malnutrition F39B2.5 "21458454 " 9021 HGNC:19391|MIM:604176|Ensembl:ENSG00000184557|HPRD:05006 suppressor of cytokine signaling 3 SOD2 Human FOXO3 up qRT-PCR;Western blotting ChIP Anti-oxidation sod-2;sod-3 "19324885 " 6648 HGNC:11180|MIM:147460|Ensembl:ENSG00000112096|HPRD:00938|Vega:OTTHUMG00000015940 "superoxide dismutase 2, mitochondrial" SOD2 Human FOXO4 up Luciferase Reporter Assay;Western blotting ChIP Anti-oxidantion sod-2;sod-3 "21536589 " 6648 HGNC:11180|MIM:147460|Ensembl:ENSG00000112096|HPRD:00938|Vega:OTTHUMG00000015940 "superoxide dismutase 2, mitochondrial" SOD2 Human FOXO1 up Luciferase Reporter Assay;Quantitative protein microarray analysis ChIP; Luciferase Reporter Assay Anti-oxidant sod-2;sod-3 "16186101 " 6648 HGNC:11180|MIM:147460|Ensembl:ENSG00000112096|HPRD:00938|Vega:OTTHUMG00000015940 "superoxide dismutase 2, mitochondrial" SOD2 Human FOXO3 up Northern; Luciferase Reporter Assay luciferase Reporter Assay+mutation;ChIP Stress resisitance sod-2;sod-3 "12239572 " 6648 HGNC:11180|MIM:147460|Ensembl:ENSG00000112096|HPRD:00938|Vega:OTTHUMG00000015940 "superoxide dismutase 2, mitochondrial" Sod2 Rat FOXO1 up qRT-PCR;Western blotting ChIP Antioxidation sod-2;sod-3 "17408630 " 24787 RGD:3732|Ensembl:ENSRNOG00000019048 "superoxide dismutase 2, mitochondrial" sod-3 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Stress response, iron/manganese superoxide dismutase" sod-3 "23312285 " 181748 WormBase:WBGene00004932 SOD (superoxide dismutase) sodh-1 C. elegans DAF-16 up Microarray;confirmed by RFP ChIP Sorbitol dehydrogenase sodh-1? "23312285 " 179627 WormBase:WBGene00010790 SOrbitol DeHydrogenase family SOX2 Human FOXO1 up qRT-PCR ChIP; Luciferase Reporter Assay;EMSA Pluripotency of embryonic stem cells "21804543 " 6657 HGNC:11195|MIM:184429|Ensembl:ENSG00000181449|HPRD:08921|Vega:OTTHUMG00000158222 SRY (sex determining region Y)-box 2 spen Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP -- din-1 "18177722 " 44205 FLYBASE:FBgn0016977 split ends Spry2 Mouse FOXO up Micoroarray;qRT-PCR ChIP Endothelial cell homeostasis "17254969 " 24064 MGI:1345138|Ensembl:ENSMUSG00000022114 sprouty homolog 2 (Drosophila) stdh-1 C. elegans DAF-16 up Microarray;confirmed by RFP ChIP "Metabolic, 17 beta-hydroxysteroid dehydrogenase" stdh-1 "23312285 " 182291 WormBase:WBGene00007363 STeroid DeHydrogenase family STK11 Human FOXO3;FOXO4 up Luciferase Reporter Assay;qRT-PCR; Western blotting ChIP; Luciferase Reporter Assay+Deletion; EMSA Cell cycle par-4 "22412893 " 6794 HGNC:11389|MIM:602216|Ensembl:ENSG00000118046|HPRD:03740 serine/threonine kinase 11 T19C9.8 C. elegans DAF-16 up Microarray;qRT-PCR DamID Nematode specific genes T19C9.8 20706209 180142 WormBase:WBGene00011844 hypothetical protein T25F10.3 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- T25F10.3 20706209 179067 WormBase:WBGene00020806 hypothetical protein TAF11 Human FOXO1 up quantitative RT-PCR ChIP -- taf-11.2;taf-11.1 "18301748 " 6882 HGNC:11544|MIM:600772|Ensembl:ENSG00000064995|HPRD:15980|Vega:OTTHUMG00000014556 "TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa" tat-4 C. elegans DAF-16 up Microarray;qRT-PCR DamID -- tat-4 20706209 174031 WormBase:WBGene00020784 Transbilayer Amphipath Transporters (subfamily IV P-type ATPase) Tcf7 Mouse FOXO1 up microarray;qRT-PCR ChIP-qPCR -- pop-1 "23733882 " 21414 MGI:98507|Ensembl:ENSMUSG00000000782|Vega:OTTMUSG00000005622 "transcription factor 7, T cell specific" THBS1 Human FOXO1 up qRT-PCR; Western blotting ChIP Angiogenesis "23677673 " 7057 HGNC:11785|MIM:188060|Ensembl:ENSG00000137801|HPRD:01765|Vega:OTTHUMG00000133665 thrombospondin 1 Thor Drosophila melanogaster dFOXO -- Luciferase Reporter Assay; Microarray ChIP Protein synthesis "18177722 " 33569 FLYBASE:FBgn0261560 CG8846 gene product from transcript CG8846-RA Thor Drosophila melanogaster dFOXO up Microarray;RNase protection assay;Luciferase Reporter Assay EMSA;ChIP -- "12893776 " 33569 FLYBASE:FBgn0261560 CG8846 gene product from transcript CG8846-RA Tlr4 Mouse FOXO1 up qRT-PCR; Luciferase Reporter Assay ChIP Inflammation "21045807 " 21898 MGI:96824|Ensembl:ENSMUSG00000039005|Vega:OTTMUSG00000000227 toll-like receptor 4 TNFSF10 Human FOXO3 up Micoraarray;qRT-PCR;Western blotting;Luciferase Reporter Assay EMSA;Luciferase Reporter Assay+Mutation Apoptosis "12351634 " 8743 HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 "tumor necrosis factor (ligand) superfamily, member 10" Tp53inp1 Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis "23059819 " 297822 RGD:631423|Ensembl:ENSRNOG00000007964 tumor protein p53 inducible nuclear protein 1 tps-1 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Stress response, trehalose-6-phosphate synthase" tps-1 "23312285 " 181778 WormBase:WBGene00006602 Trehalose 6-Phosphate Synthase tps-2 C. elegans DAF-16 up Microarray;confirmed by GFP ChIP "Stress response, trehalose-6-phosphate synthase" tps-2 "23312285 " 3565050 WormBase:WBGene00006603 Trehalose 6-Phosphate Synthase TRADD Human FOXO1 up qRT-PCR;Western blotting; Luciferase Reporter Assay Luciferase Reporter Assay;EMSA Apoptosis "12446787 " 8717 HGNC:12030|MIM:603500|Ensembl:ENSG00000102871|HPRD:04610|Vega:OTTHUMG00000137519 TNFRSF1A-associated via death domain Trib3 Rat FOXO1 down Western blotting; qRT-PCR; Luciferase Reporter Assay ChIP; Luciferase Reporter Assay Signaling tansduction "16906224 " 246273 RGD:708432|Ensembl:ENSRNOG00000007319 tribbles homolog 3 (Drosophila) TRIM63 Human FoxO1; FoxO3 ; FoxO4 up Luciferase Reporter Assay ChIP; Luciferase Reporter Assay+Mutation Metabolism "18612045 " 84676 HGNC:16007|MIM:606131|Ensembl:ENSG00000158022|HPRD:05843|Vega:OTTHUMG00000007510 "tripartite motif containing 63, E3 ubiquitin protein ligase" Tsc1 Mouse FOXO3 up Western blotting; qRT-PCR ChIP; Luciferase Reporter Assay+Mutation Metabolism "20371605 " 64930 MGI:1929183|Ensembl:ENSMUSG00000026812|Vega:OTTMUSG00000011747 tuberous sclerosis 1 TXN2 Human FOXO3 up qRT-PCR;Western blotting ChIP Antioxidation trx-2 "19324885 " 25828 HGNC:17772|MIM:609063|Ensembl:ENSG00000100348|HPRD:07161|Vega:OTTHUMG00000150596 thioredoxin 2 TXNIP Human FOXO1;FOXO3 up Western blotting ChIP Cell death arrd-6 "21873430 " 10628 HGNC:16952|MIM:606599|Ensembl:ENSG00000117289|HPRD:05964|Vega:OTTHUMG00000013755 thioredoxin interacting protein TXNIP Human FOXO1 down Mcroarray;Luciferase Reporter Assay ChIP Oxidative stress response arrd-6 "18301748 " 10628 HGNC:16952|MIM:606599|Ensembl:ENSG00000117289|HPRD:05964|Vega:OTTHUMG00000013755 thioredoxin interacting protein TXNIP Human FOXO1 down qRT-PCR ChIP; EMSA Metbolism arrd-6 "23803610 " 10628 HGNC:16952|MIM:606599|Ensembl:ENSG00000117289|HPRD:05964|Vega:OTTHUMG00000013755 thioredoxin interacting protein Txnip Rat FOXO1;FOXO3 up qRT-PCR ChIP Apoptosis arrd-6 "23059819 " 117514 RGD:620886|Ensembl:ENSRNOG00000021201 thioredoxin interacting protein ubh-4 C. elegans DAF-16 down GFP ChIP-seq;GFP+Mutation Protesome activity ubh-4 "23770237 " 174289 WormBase:WBGene00006724 UBiquitin C-terminal Hydrolase (family 1) Ucp1 Mouse FOXO1 up qRT-PCR ChIP Energy expenditure "22405073 " 22227 MGI:98894|Ensembl:ENSMUSG00000031710 "uncoupling protein 1 (mitochondrial, proton carrier)" UCP2 Human FOXO3 up qRT-PCR;Western blotting ChIP Antioxidation "19324885 " 7351 HGNC:12518|MIM:601693|Ensembl:ENSG00000175567|HPRD:03410|Vega:OTTHUMG00000168095 "uncoupling protein 2 (mitochondrial, proton carrier)" ucp-4 C. elegans DAF-16 up mcherry ChIP Neuro-protective ucp-4 "22956852 " 179315 WormBase:WBGene00006729 UnCoupling Protein (mitochondrial substrate carrier) ugt-1 C. elegans DAF-16 down Semi-quantitative RT-PCR;GFP EMSA;Mutation Development;lifepsan;metabolism ugt-1 "15253933 " 179449 WormBase:WBGene00007072 UDP-GlucuronosylTransferase VCAM1 Human FOXO1 up qRT-PCR ChIP Cell adhesion and signal transduction "22405072 " 7412 HGNC:12663|MIM:192225|Ensembl:ENSG00000162692|HPRD:01888|Vega:OTTHUMG00000010982 vascular cell adhesion molecule 1 VEGFA Human FOXO3 down Western blotting and qRT-PCR ChIP "Vasculogenesis, angiogenesis" "21860419 " 7422 HGNC:12680|MIM:192240|Ensembl:ENSG00000112715|HPRD:01889|Vega:OTTHUMG00000014745 vascular endothelial growth factor A W Drosophila melanogaster dFOXO up Hid-lacZ;RNA in situ hybridization;qRT-PCR ChIP Apotopsis wht-1 "17183370 " 31271 FLYBASE:FBgn0003996 white W Drosophila melanogaster dFOXO up qRT-PCR ChIP Apotopsis wht-1 "20624856 " 40009 FLYBASE:FBgn0003997 Wrinkled Y37E11B.7 C. elegans DAF-16 up Microarray;qRT-PCR DamID Nematode specific genes Y37E11B.7 20706209 177121 WormBase:WBGene00021379 hypothetical protein ZC443.3 C. elegans DAF-16 up Microarray;qRT-PCR DamID Nematode specific genes ZC443.3 20706209 179758 WormBase:WBGene00013898 hypothetical protein