Welcome to FOXODB

FOXODB is a database aimed at manually collecting experimentally verified direct targets of FOXO transcription factors (FOXOs). FOXOs are at the interface of crucial cellular processes, orchestrating programs of gene expression that regulate apoptosis, cell-cycle progression, and oxidative stress resistance. In invertebrates, there is only one FOXO gene, termed daf-16 in the worm and dFOXO in the fly. In mammals, there are four FOXO genes, FOXO1, FOXO3, FOXO4, and FOXO6. Currently, FOXODB collects about 300 entries including more than 200 FOXOs direct targets. We believe FOXODB will be a valuable resource for related research community.

There are strict rules to collect a gene to FOXODB: (1) the gene must be differentially expressed in FOXO(+) versus FOXO(-); (2) FOXO could bind to the promoter region of the gene; and (3) since the high false positive of high throughput experiment, only tranditional experimental evidences were used.