李彦辉 博士

北京大学心血管研究所 助理研究员


Dr. Yan-Hui Li

Institute of Cardiovascular Sciences,Peking University Health Science Center.

#38 Xueyuan Road, Haidian District, Beijing 100191, China.

E-mail: liyanhui@bjmu.edu.cn

Tel: 010-82805008

Web: http://lyh.pkmu.cn/

2012年-今，北京大学心血管研究所 助理研究员

2011年-2012年，中科院计算机网络信息中心 助理研究员


2012-Now, Assistant professor, Institute of Cardiovascular Sciences,Peking University Health Science Center.

2011-2012, Assistant professor, Computer Network Information Center, Chinese Academy of Sciences.

(1)生物信息学。

(2)整合组学数据研究心血管疾病的发病机制。


(1) Bioinformatics.

(2) Integrating omics data to understand the mechanism of cardiovascular disease.

Note:  * Corresponding author,   # Co-first author.


[25]Xing-Zhong Zhang,Yan-Li Pang,Xian Wang*,Yan-Hui Li* Computational characterization and identification of human polycystic ovary syndrome genes Scientific Reports,8:12949 (2018) （共同通讯作者).

[24] Yan-Hui Li* and Gaigai Zhang. Network-based characterization and prediction of human DNA repair genes and pathways. Scientific Reports, 8, Article number: 45714 (2017) doi:10.1038/srep45714 （第一作者，通讯作者）

[23] Yan-Hui Li*, Gaigai Zhang, Nanping Wang*. Systematic characterization and prediction of human hypertension genes. Hypertension, 2017 Feb;69(2):349-355. （第一作者，共同通讯作者）

[22] Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li YH, Xu Q, Wang X, Kong W. Shift of macrophage phenotype due to cartilage oligomeric matrix protein deficiency drives atherosclerotic calcification. Circ Res, 2016 Jul 8;119(2):261-76. (参与作者)

[21] Fang L, Zhang M, Li YH, Liu Y, Cui Q, Wang N. Ppargene: A database of experimentally verified and computationally predicted ppar target genes. PPAR Res, 2016;2016:6042162；(参与作者)

[20] Zhou Y, Zeng P, Li YH, Zhang Z, Cui Q. Sramp: Prediction of mammalian n6-methyladenosine (m6a) sites based on sequence-derived features. Nucleic Acids Res, 2016;44:e91；(参与作者)

[19] C. Gao, Y. Fu, Yan-Hui Li, X. Zhang, L. Zhang, F. Yu, S. S. Xu, Q. Xu, Y. Zhu, Y. Guan, X. Wang, and W. Kong, Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol, 2016 Jan;36(1):108-21.(参与作者)

[18]Yan-Hui Li, G.G. Zhang, Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans, Oncotarget, (2016). PMID: 27027346(第一作者，通讯作者)

[17] Yan-Hui Li#, C. Wang#, Z. Miao#, X. Bi#, D. Wu#, N. Jin#, L. Wang, H. Wu, K. Qian, C. Li, T. Zhang, C. Zhang, Y. Yi, H. Lai, Y. Hu, L. Cheng, K. S. Leung, X. Li, F. Zhang, K. Li, and D. Wang, ViRBase: a resource for virus-host ncRNA-associated interactions. Nucleic Acids Res, 2015. 43: p. D578-82（共同第一作者）

[16] Yan-Hui Li*, G. Zhang, and Q. Cui*, PPUS: a web server to predict PUS-specific pseudouridine sites. Bioinformatics, 2015 Oct 15; 31(20):3362-4.（第一作者，共同通讯作者）

[15] Zhengju Chen, Xu Zhang, Lei Ying, Dou Dou, Yan-Hui Li, Yun Bai, Juan Liu, Limei Liu, Han Feng, Xiaoxing Yu, Susan Wai-Sum Leung, Paul M. Vanhoutte and Yuansheng Gao. cIMP synthesized by sGC as a mediator of hypoxic contraction of coronary arteries. Am J Physiol Heart Circ Physiol, 2014 Aug 1;307(3):H328-36.(参与作者)

[14] Gai-Gai Zhang, Huai-Qiu Cai, Yan-Hui Li, Yu-Bin Sui, Jin-Sheng Zhang, Jin-Rui Chang,Ming Ning, Yang Wu,Chao-Shu Tang, Yong-Fen Qi, Xin-Hua Yin, Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase, Peptides, 2013 October, 48: 156-165.(参与作者)

[13] Y Wang, L Chen, B Chen, X Li, J Kang, K Fan, Y Hu, J Xu, L Yi, J Yang, Y Huang, L Cheng, Yan-Hui Li, C Wang, K Li, X Li, J Xu and D Wang, Mammalian ncRNA-disease repository: a global view of ncRNA-mediated disease network, Cell Death and Disease, (2013) 4, e765; (参与作者)

[12] Jianzhen Xu#and Yan-Hui Li#, miRDeathDB: a database bridging microRNAs and the programmed cell death. Cell Death & Differentiation, (29 June 2012)（共同第一作者)

[11] Yan-Hui Li, Jian-Hui Li, Xin Song, Kai Feng, and Yuan-Chun Zhou, Predicting aging-genes in Drosophila melanogaster by integrating network topological features and functional categories, International Journal of Knowledge Discovery in Boinformatics, 2012, 3(2): 16-26.（第一作者）

[10] Yan-Hui Li, Meng-Qiu Dong, Zheng Guo, Systematic analysis and prediction of longevity genes in Caenorhabditis elegans, Mechanism of Ageing and Development, 2010, 131(11-12):700-9.（第一作者）

[9] Da Yang#, Yan-Hui Li#, Hui Xiao#, Qing Liu, Min Zhang, Jing Zhu, Wencai Ma, Chen Yao, Jing Wang, Dong Wang, Zheng Guo, Baofeng Yang. Gaining confidence in biological interpretation of the microarray data: the functional consistence of the significant GO categories. Bioinformatics, 2008, 24(2):265-271.（共同第一作者）

[8] Yan-Hui Li, Zheng Guo, Chunfang Peng, Qing Liu, Wencai Ma, Jing Wang, Chen Yao, Min Zhang, Jing Zhu. Identifying cancer genes from cancer mutation profiles by cancer functions. Sci China C Life Sci, 2008, 51(6):569-574. (第一作者)

[7] Min Zhang, Chen Yao, Zheng Guo, Jinfeng Zou, Lin Zhang, Hui Xiao, Dong Wang, Dang Yang, Xue Gong, Jing Zhu, Yan-Hui Li, Xia Li. Apparently low reproducibility of true differential expression discoveries in microarray studies. Bioinformatics, 2008, 24(18):2057-2063. (参与作者)

[6] Yan-Hui Li, Zheng Guo, Wencai Ma, Da Yang, Dong Wang, Min Zhang, Jing Zhu, Guocai Zhong, Yongjin Li, Chen Yao, Jing Wang. Finding finer functions for partially characterized proteins by protein-protein interaction networks. Chinese Science Bulletin, 2007, 52(24):3363-3370. (第一作者)

[5] Mingzhu Zhu, Lei Gao, Zheng Guo, Yan-Hui Li, Jing Wang, Dong Wang. Globally Predicting protein functions based on co-expressed protein-protein interaction networks and ontology taxonomy similarities. Gene, 2007，391(1-2):113-9.(参与作者)

[4] Gao Lei, Li Xia, Guo Zheng, Zhu MingZhu, Yan-Hui Li, Rao ShaoQi Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile, Sci China C Life Sci, 2007, 50(1):125-134. (参与作者）

[3] Jing Zhu, Jing Wang, Zheng Guo, Min Zhang, Da Yang, Yan-Hui Li, Dong Wang, Guohua Xiao. GO-2D: identifying 2-dimensional cellular-localized functional modules in Gene Ontology. BMC Genomics, 2007, 8:30.(参与作者)

[2] Zheng Guo, Yongjin Li, Xue Gong, Chen Yao, Wencai Ma, Dong Wang, Yan-Hui Li, Jing Zhu, Min Zhang, Da Yang, Jing Wang. Edge-based scoring and searching method for identifying condition-responsive protein-protein interaction sub-network. Bioinformatics, 2007, 23(16):2121-2128. (参与作者)

[1] Dong Wang, Yingli Lv, Zheng Guo, Xia Li, Yan-Hui Li, Jing Zhu, Da Yang, Jianzhen Xu, Chengguang Wang, Shaoqi Rao, Baofeng Yang. Effects of replacing the unreliable cDNA microarray measurements on the disease classification based on gene expression profiles and functional modules. Bioinformatics, 2006, 22(23):2883-2889. (参与作者)

1. Bioninformatics tools or database:

(1) FOXODB: http://lyh.pkmu.cn/foxodb

(2) PPUS: http://lyh.pkmu.cn/ppus

(3) miRDeathDB: http://lyh.pkmu.cn/mirdeathdb/

(4) ViRBase: http://www.rna-society.org/virbase/

(5) PPARgene: http://http://www.ppargene.org/

2. We also developed several management information systems for our insititute and friends. The codes are free for academic use.

(1) http://ics.pkmu.cn/ms/

(2) http://ics.pkmu.cn/yy/

(3) http://ics.pkmu.cn/xt/